In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival
نویسندگان
چکیده
منابع مشابه
Ex Situ Normothermic Machine Perfusion of Donor Livers.
In contrast to conventional static cold preservation (0-4 °C), ex situ machine perfusion may provide better preservation of donor livers. Continuous perfusion of organs provides the opportunity to improve organ quality and allows ex situ viability assessment of donor livers prior to transplantation. This video article provides a step by step protocol for ex situ normothermic machine perfusion (...
متن کاملNormothermic Perfusion in the Assessment and Preservation of Declined Livers Before Transplantation: Hyperoxia and Vasoplegia—Important Lessons From the First 12 Cases
BACKGROUND A program of normothermic ex situ liver perfusion (NESLiP) was developed to facilitate better assessment and use of marginal livers, while minimizing cold ischemia. METHODS Declined marginal livers and those offered for research were evaluated. Normothermic ex situ liver perfusion was performed using an erythrocyte-based perfusate. Viability was assessed with reference to biochemic...
متن کاملControlled Donation After Circulatory Determination of Death in Spain.
We read with interest Magliocca’s editorial regarding our recent publication on the perioperative management of liver recipients of uncontrolled or unexpected donation after circulatory determination of death (uDCD) (1,2). One comment in particular, that “the ethical and legal environment of transplantation in Spain preclude[s] the use of [controlled donation after circulatory determination of ...
متن کاملFirst Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.
BACKGROUND Exposure of donor liver grafts to prolonged periods of warm ischemia before procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft loss. Due to unavoidable prolonged ischemic time before procurement in donation after cardiac death (DCD) donation in 1 participating center, each liver graft of this center was pretreated with the new machine perfusion...
متن کاملFunctional Implications of Biochemical and Molecular Characteristics of Donation After Circulatory Death Livers
UNLABELLED In aggregate, livers donated after circulatory death (DCD) provide lower rates of graft and patient survival compared to brain dead donors (DBD). A method to identify DCD livers likely to perform well would lead to better decision-making regarding which livers to use and which to discard and is an important unmet clinical need. We hypothesized that the ischemic time between extubatio...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2019
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.15241